How do I deal with questions that do not seem applicable for a particular patient group or project?
Usually the best strategy is to administer the entire scale, but plan a priori to evaluate the data focusing on the target (appropriate) questions only and the entire (validated) scale. If pilot testing with the target population (not just investigator opinion) reveals a truly not applicable question, it can be deleted but one loses the ability to compare data to available reference data. At times, individual patients may feel that a given item is not applicable to them. An example would be the FACT-G Physical Well-Being item “I am bothered by side effects of treatment” where patients may feel as though they should skip the item because they are not currently receiving any treatment. In this circumstance, they should be encouraged to select the best response according to their level of “bother”. If they are not receiving any treatment then they are not likely bothered by any side effects, so “not at all” would make the most sense. Patients should be encouraged to select the best possib
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