How do I restrict my search to structures which contain a certain substructure and show some anti-viral anti-AIDS activity?
First, draw your structure as usual and transfer it into one of the query data fields. Select Substructure Search for that field. Then take one of the yet unused data input rows and switch its query type to AIDS Screen Result. The menu below the data input field will change. Select from that menu the entry labelled Active. Make sure that the Connect query fields radiobutton is set to AND, so that only structures which match the desired AIDS screening result and the substructure are displayed. It does not matter which field you are using for the structure query, and which field for the AIDS screening result – the software will always re-order the query to achieve maximum performance (meaning that the AIDS screening results is always checked first).
