How do I stop the killer bees from coming out of their hive, or the giant ants from their hole?
Insect colonies have finite populations. With bees, you can speed up the process by disturbing the hive. If you really just want to stop them from coming out for a little while, stand on the hive/hole or get someone else to do it (a nice use for a well-trained pet). Certain items can be useful here.