How do I work with ReWire?
The ReWire protocol governs the tempo synchronization and exchange of audio between two or more ReWire-compatible programs, whereby one program fills the role of ‘Host’ and the others that of ‘Clients’. The host is the boss, so to speak: it is the program that lays down the tempo, with the rest ‘slavishly’ following its lead, and it alone has access to the audio interface. For the audio signals of the clients to be heard, they have to be routed to the mixer of the host application, where they can profit from all the host’s plug-ins; however in their own mixers, client applications no longer have access to VST or AudioUnits plug-ins, since these are now the exclusive property of the ReWire host. To run Melodyne in ReWire mode, you need first to establish a ReWire connection. See the following question.