How do insulin-sensitizing medications work?
Metformin/Glyciphage works primarily by suppressing hepatic glucose production, increasing glucose utilization in peripheral tissues. It may also reduce intestinal glucose absorption. Since it does not stimulate production of insulin, it does not cause hypoglycemia if used alone. Rosiglitazone (Rezult) — work primarily by improving sensitivity to insulin in muscle and adipose (fat) tissue and also by inhibiting hepatic glucose production. If hypoglycemia is experienced on either type of medication, it is most likely due to insufficient caloric intake, rather than a direct result of the medication. These medications may also help improve cholesterol and triglycerides levels, and may restore ovulation in premenopausal women with PCOS or diabetes.
Metformin/Glucophage works primarily by suppressing hepatic glucose production, increasing glucose utilization in peripheral tissues. It may also reduce intestinal glucose absorption. Since it does not stimulate production of insulin, it does not cause hypoglycemia if used alone (though hypoglycemia may result if used with insulin, a sulfonylurea, or with consumption of an excessive amount of alcohol). Metformin is metabolized by the kidneys. The thiazolidinediones (glitazones or TZDs) troglitazone (Rezulin, which was taken off the market on March 21, 2000), rosiglitazone maleate (Avandia) and pioglitazone hydrochloride (Actos) work primarily by improving sensitivity to insulin in muscle and adipose (fat) tissue and also by inhibiting hepatic glucose production. They are metabolized by the liver and excreted into the bile. If hypoglycemia is experienced on either type of medication, it is most likely due to insufficient caloric intake, rather than a direct result of the medication. The
Metformin/Glucophage works primarily by suppressing hepatic glucose production, increasing glucose utilization in peripheral tissues. It may also reduce intestinal glucose absorption. Since it does not stimulate production of insulin, it does not cause hypoglycemia if used alone (though hypoglycemia may result if used with insulin, a sulfonylurea, or with consumption of an excessive amount of alcohol). Metformin is metabolized by the kidneys. The thiazolidinediones (glitazones or TZDs) — troglitazone (Rezulin, which was taken off the market on March 21, 2000), rosiglitazone maleate (Avandia) and pioglitazone hydrochloride (Actos) — work primarily by improving sensitivity to insulin in muscle and adipose (fat) tissue and also by inhibiting hepatic glucose production. They are metabolized by the liver and excreted into the bile. If hypoglycemia is experienced on either type of medication, it is most likely due to insufficient caloric intake, rather than a direct result of the medication.
Furthermore, the use of Avandia for the treatment of PCOS is even less understood and less accepted by long-term effects of using Avandia to treat PCOS are still unknown Callalil’s PCOS Pages provide information for women with polycystic ovarian syndrome (also known as Stein-Leventhal syndrome) – including info about infertility and herbal remedies. with PCOS with insulin-lowering medications such as metformin (also known as Glucophage), Avandia (rosiglitazone) and in women with PCOS by treating the underlying Another diabetes drug, Glucophage (metformin), has been used to treat PCOS. The only thing new here is the a different drug for PCOS.
