How do people become leptin-resistant?
This is the subject of much research. I believe people become leptin-resistant by the same general mechanism that people become insulin-resistant: By overexposure to high levels of the hormone. High blood glucose levels cause repeated surges in insulin and this causes one’s cells to become “insulin-resistant” which leads to further high levels of insulin and diabetes. It is much the same as being in a smelly room for a period of time. Soon, you stop being able to smell it, because the signal no longer gets through. I believe the same happens with leptin. It has been shown that as sugar gets metabolized in fat cells, fat releases surges in leptin, and I believe that those surges result in leptin-resistance just as it results in insulin-resistance. I enjoyed your short section on body temperature. Why is having a lower body temperature is so important? Almost all mechanisms that extend lifespan in many different organisms result in lower temperature. Flowers are kept in a refrigerator at