How do the papillary infoldings of Graves disease compare and contrast with papillae of papillary thyroid cancer?
Graves’ papillae are generally within a follicle, small, with preserved nuclear polarity, and are present diffusely in the gland. Papillary carcinoma papillae are localized to the tumor, usually larger, with disturbed nuclear polarity, and frequently a more prominent vascular core. The nuclear characteristics of papillary carcinoma (clear chromatin, pseudoinclusions) are not features of Graves’ disease.
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