How do the varying cardiac stress agents compare with respect to myocardial oxygen consumption and induction of ischemia?
Rate-pressure product (RPP = heart rate x blood pressure, BPM-mmHg) is a work index which is correlated with myocardial oxygen consumption (Gobel et al, Cohen et al). Summarized below are 6 studies comparing RPP measured in the same patients at peak levels of exercise vs. dobutamine and exercise vs. TAP. Compared to dobutamine, TAP induces myocardial oxygen consumption which is closer to that seen at peak exercise.
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