How do we know elastin is involved in wrinkle formation?
A lack of elastin or genetic abnormalities affecting elastic fibers in skin, as evidenced in Costello Syndrome, Cutis Laxa and Pseudoxanthoma Elasticum respectively, lead to premature aging most noticeably characterized by wrinkling and folding of the skin in children (pre-teenage) suffering from these illnesses. Keep in mind that there is nothing wrong with collagen in the skin of these children.
