How does carvedilol, metoprolol, bisoprolol decrease remodeling & cause upregulation?
Any blocker (antagonist) leads to up regulation and any agonist leads to down regulation of the receptors (an important Pharmacodynamic role). The effect on remodeling is related to reversing the factors that stimulate remodeling (e.g. ischemia and hypertension) and to inhibiting the angiotensin system by inhibiting rennin release (Angiotensin II is a potent stimulator for remodeling).