How Does DXM Compare With Other Dissociatives?
Third and especially fourth plateau DXM experiences seem to resemble ketamine experiences, and based on reports of people who have done both, the similarity is considerable. This is not surprising, since both DXM and ketamine block NMDA receptors. Since v3.0 of the FAQ I have heard from PCP users who have tried DXM; all of them say that the two share little in common except at very high doses of DXM, and that even then the experiences are significantly different. PCP stands somewhat alone among dissociatives due to its unique neuropharmacology. The lower DXM plateaus seem to show a number of differences from other dissociatives. This is most likely due to DXM’s unique potency at the dopamine reuptake site (the PCP2 receptor) and the sigma receptor. DXM’s ability to block dopamine reuptake is probably the biggest factor in its popularity at lower plateaus; neither ketamine nor PCP have substantial ability to do this. When DXM is taken in divided doses, or when it is taken with an inhibi
