How does Glyburide-Metformin / Generic Glucovance work?
Glyburide acts on sulfonyl urea receptor on pancreatic beta cell membrane. This causes depolarization by reducing the conductance of ATP sensitive potassium channels. This in turn increases the calcium influx and insulin release. Metformin suppresses hepatic gluconeogenesis and glucose output from liver. Metformin enhances insulin mediated glucose disposal in muscle and fat. Metformin also enhances GLUT1 transport from intracellular site to plasma membrane. The actions of the two main active ingredients of Glucovance helps in treating diabetes mellitus of type 2 category.
