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The nitro group of Metronidazole is reduced by certain redox proteins operative only in anaerobic microbes to highly reactive nitro radical, which exerts cytotoxicity by damaging DNA and other biomolecules. Metronidazole causes DNA helix destabilization and strand breakage. Metronidazole has been found to inhibit cell mediated immunity, to induce mutagenesis and to cause radiosensitization.
