How does one choose between a 1-dose or 2-dose vaccination programme when vaccinating against M. hyopneumoniae?

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How does one choose between a 1-dose or 2-dose vaccination programme when vaccinating against M. hyopneumoniae?

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It is generally expected that a 2-dose vaccination programme would present greater efficacy than one using a single dose. This is because the second dose of vaccine is able to induce a booster effect of animals immune systems. Furthermore, 2-dose vaccination programmes are able to overcome more efficaciously the barrier of maternal antibodies coming from colostrum, i.e., they reduce the risk of partial or total neutralisation of the vaccinal antigen. It is recommended that vaccination be delayed in 1-dose programmes so as to avoid partial or total neutralisation of the antigen, thereby reducing the risk of losing vaccinal activity. It is essential, for each farm, to determine, by using serology and / or PCR, the dynamics of infection by Mycoplasma hyopneumoniae. It can generally be expected that vaccination with two doses is profitable on those farms on which the animals undergo very early infections (during lactation), early ones (during transition) or late ones (in the first few week

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