How does the alpha-2 agonist, apraclonidine decrease secretions from the ciliary epithelium in the eye when the ciliary epithelium has beta-receptors?
The ciliary epithelium cells have both alpha2-receptors and beta-receptors, activation of the alpha2-receptor or blockade of the beta-receptor will decrease secretions. Of the two, the beta-receptors are the more important receptor. This is why beta-blockers such as Timolol are the main agents used in the chronic treatment of glaucoma.
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