How does Zestra compare to the L-Arginine and menthol-based products on the market?
To set the record straight, there is no valid scientific basis for the topical use of L-Arginine that is a commonly used ingredient in the “novelty-type creams, lotions, and gels”. L-arginine (an amino acid) is a highly polar, water-soluble molecule and will not cross cell membranes to any appreciable extent. L-arginine is commonly included as an ingredient in “novelty-type” topical products as a “marketing ploy” to suggest a reference to nitric oxide formation and then attempt to link it to the known chemical pathways / actions of Viagra. Zestra does not include L-arginine in its formulation since there is no scientific merit to warrant its use when topically applied. As pharmaceutical scientists & sexual medicine researchers we know that the sensory effects from the use of menthol-based products are almost entirely due to their ‘menthol’ content (menthol is simply a chemical irritant). According to the pharmaceutical reference book, Remington’s Pharmaceutical Sciences (18th) edition,
