How Effective Is Coreg?
May, 1995 – We studied the effectiveness and safety of Coreg use in heart failure patients with idiopathic or ischemic cardiomyopathy. Sixty heart failure patients from class 2 to class 4, with EF of 35% or less, were in the study. Coreg dose was raised over one month from 6.25 to 25mg twice a day or 50mg twice a day for patients over 165 pounds. Coreg was continued for 3 months. Coreg lowered heart rate and the resistance against which the heart must pump. EF increased 52% in Coreg patients. Coreg patients also reported improved heart failure symptoms. Peak oxygen consumption during exercise (Vo2max) did not change. Long-term Coreg therapy improves “at-rest” heart function and symptoms in heart failure patients. Title: Carvedilol improves left ventricular function and symptoms in chronic heart failure: a double-blind randomized study.