How high is the stack?
King Features, for instance, estimates that it gets up to 2,000 submission packages a month, but only about 150 get any serious consideration, and those are cut down to 50 or so in a short time. Of this, only two or three comic strips will actually reach fruition. And two years later, three of them will have been canceled. A smaller syndicate may be more approachable. But a smaller syndicate may have a difficult time attracting the attention of the best newspaper editors.