How is scaling affected by node distribution over different latency networks, e.g. WAN vs LAN?

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How is scaling affected by node distribution over different latency networks, e.g. WAN vs LAN?

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High latency WANs will hurt performance for operations involving mnesia transactions. This pretty much amounts to any modification of topology: queue add/delete, exchange add/delete, binding add/delete. Publishes and get/consume are unaffected.