How is tyrosinemia 1 inherited?
This condition is inherited in an autosomal recessive manner. It affects both boys and girls equally. Everyone has a pair of genes that make the FAH enzyme. In children with tyrosinemia 1, neither of these genes works correctly. These children inherit one non-working gene for the condition from each parent. Parents of children with tyrosinemia 1 rarely have the condition themselves. Instead, each parent has a single non-working gene for the condition. They are called carriers. Carriers do not have the condition because the other gene of this pair is working correctly. When both parents are carriers, there is a 25% chance in each pregnancy for the child to have tyrosinemia 1. There is a 50% chance for the child to be a carrier, just like the parents. And, there is a 25% chance for the child to have two working genes. Genetic Counseling is available to families who have children with tyrosinemia 1. Genetic counselors can answer your questions about how the condition is inherited, choices
