How many clinical studies have evaluated the efficacy and safety of LYRICA as adjunctive therapy for partial onset seizures?
A1: LYRICA has been studied in three 12-week, double-blind, placebo-controlled, multicenter clinical studies involving 1,052 adults with partial onset seizures. A highly refractory patient population was included in all LYRICA epilepsy studies. Patients who were enrolled had partial onset seizures with or without secondary generalization and were not adequately controlled on 1 to 3 concomitant antiepileptic drugs (AEDs).7,9,10 The mean duration of epilepsy in these 3 studies was 25 years, and the mean and median baseline seizure frequencies were 22.5 and 10 seizures per month. Approximately half of the patients were taking 2 concurrent AEDs at baseline. Up to 51% seizure frequency reduction with LYRICA 600 mg/day. In an additional TID study, seizure frequency was significantly reduced by up to 43% with LYRICA 600 mg/day. LYRICA reduced seizure frequency across the dose range by 50% or more in up to 51% of patients In this study, approximately 70% of patients were taking 2 or more AEDs
A1: LYRICA has been studied in three 12-week, double-blind, placebo-controlled, multicenter clinical studies involving 1,052 adults with partial onset seizures. A highly refractory patient population was included in all LYRICA epilepsy studies. Patients who were enrolled had partial onset seizures with or without secondary generalization and were not adequately controlled on 1 to 3 concomitant antiepileptic drugs (AEDs).7,9,10 The mean duration of epilepsy in these 3 studies was 25 years, and the mean and median baseline seizure frequencies were 22.5 and 10 seizures per month. Approximately half of the patients were taking 2 concurrent AEDs at baseline. Up to 51% seizure frequency reduction with LYRICA 600 mg/day. In an additional TID study, seizure frequency was significantly reduced by up to 43% with LYRICA 600 mg/day.
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