If an adult healthcare worker has a negative measles titer, should she receive one or two doses of MMR and what is the interval between the two doses?
It depends on the person’s disease and vaccination history. If she has documentation of physician-diagnosed measles, this is adequate evidence of immunity and no doses of vaccine are recommended. If she has no documentation of physician-diagnosed measles but has documentation of one prior dose of live measles vaccine on or after the first birthday, give one dose of MMR. If she has no documentation of physician-diagnosed measles but documentation of two doses of live measles vaccine, this is considered adequate evidence of immunity. The negative titer is probably due to a serologic test that is not sensitive enough to detect antibodies, but since a 2-dose vaccine failure is theoretically possible we recommend you give one dose of MMR anyway. If she has no documentation of physician-diagnosed measles or documentation of any doses of live measles vaccine, give two doses of MMR separated by 28 days.
Related Questions
- If an adult health-care worker has a negative measles titer, should she receive one or two doses of MMR and what is the interval between the two doses?
- If an adult healthcare worker has a negative measles titer, should she receive one or two doses of MMR and what is the interval between the two doses?
- If serologic antibody levels are below protective levels for measles in an adult, is it recommended that they receive a repeat MMR?
