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Is BD ProEx™ C reagent just like p16?

April 26, 2017BD p16 proex™ Reagent

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Is BD ProEx™ C reagent just like p16?

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No, the staining patterns are different. BD ProEx™ C is a reagent containing antibodies to MCM2 and TOP2A proteins. The p16 reagent is an antibody specific to p16. BD ProEx™ C reagent produces a nuclear staining pattern while the p16 antibody stains both the nucleus and cytoplasm. The 2005 USCAP conference in the Clinical Reference Folder (980-06163-00) describes the research studies correlating p16, MCM2, and Cyclin E as molecular markers in IHC and ICC formats.