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Is elevated mean platelet volume associated with a worse outcome in patients with acute ischemic cerebrovascular events?

April 26, 2017acute associated elevated ischemic mean outcome Patients PLATELET volume worse

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Is elevated mean platelet volume associated with a worse outcome in patients with acute ischemic cerebrovascular events?

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GROUND AND PURPOSE: Increased mean platelet volume (MPV), indicating higher platelet reactivity, is associated with an increased risk of myocardial infarction. Higher levels of MPV have been found in patients with acute ischemic stroke than in control subjects. Data from smaller studies regarding an association between MPV and stroke severity and outcome have been controversial. If such an association exists, MPV might help to identify patients at increased risk of a severe course of acute cerebrovascular disease. METHODS: Within a multicenter, cross-sectional study nested in a cohort, we analyzed the relation between MPV and stroke severity as determined by the modified Rankin Scale after 1 week in 776 patients with acute ischemic stroke or transient ischemic attack. By multivariate logistic regression modeling, we determined the influence of MPV on stroke severity, adjusting for potential confounding factors. RESULTS: Patients within the highest quintile of MPV had a significantly hi