Is glycaemia or insulin dose the stronger risk factor for coronary artery disease in type 1 diabetes?
Baqiyyah Conway University of Pittsburgh, Department of Epidemiology, Pittsburgh, PA, USA Tina Costacou University of Pittsburgh, Department of Epidemiology, Pittsburgh, PA, USA Trevor Orchard University of Pittsburgh, Department of Epidemiology, Pittsburgh, PA, USA, OrchardT{at}edc.pitt.edu’ + u + ‘@’ + d + ”//–> Although coronary artery disease (CAD) is the leading cause of death in type 1 diabetes (T1D), the mechanisms responsible for the greatly increased risk are poorly understood. In particular, the role of glycaemic control is controversial with one study suggesting it predicts CAD mortality but not incidence. In this analysis, of the Pittsburgh Epidemiology of Diabetes Complications study cohort of T1D, we examine whether risk factors differ for CAD morbidity and mortality, with a specific focus on HbA1c and insulin dose. Participants (n=592) were followed for 18 years for incident non-fatal and fatal CAD. Cox stepwise regression was used to determine the independent risk fac
