Is GST gene polymorphism a risk factor in developing exfoliation syndrome?

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Is GST gene polymorphism a risk factor in developing exfoliation syndrome?

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Yilmaz A ; Tamer L ; Ates NA ; Yildirim O ; Yildirim H ; Atik U Ophthalmology Department, Mersin University Faculty of Medicine, Mersin, Turkey. aycayilmaz@mersin.edu.tr PURPOSE: To evaluate the distribution of GSTM1, GSTP1, and GSTT1 gene polymorphisms in exfoliation syndrome (XFS) and the possible associations between the presence of exfoliation syndrome and glutathione S-transferase (GST) gene polymorphisms. METHODS: Using a real-time polymerase chain reaction, GSTM1, GSTP1, and GSTT1 gene polymorphisms were detected in 60 patients with exfoliation syndrome, among which 71.7% had exfoliative glaucoma (43 patients), 16.7% had XFS with elevated intraocular pressure (IOP) (10 patients), and 11.7% had XFS only (7 cases), and in 65 otherwise healthy control group of similar age. RESULTS: Although the exfoliation syndrome group presented a higher prevalence of the GSTM1 null and GSTP1 Ile/Val genotypes than the control group, this increase was not statistically significant. GSTT1 null and