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Is Heightened Liver Damage with HCV 1b Due to Free Radicals?

damage free radicals gastroenterology HCV heightened infectious disease liver pathogenesis
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Is Heightened Liver Damage with HCV 1b Due to Free Radicals?

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Enhanced free radical production in patients with chronic hepatitis C virus 1b may cause the exacerbated liver damage often seen with this genotype. Hepatitis C virus (HCV) infection is associated with increased lipoperoxidation, which may lead to interference with mitochondrial function with possible depletion of mitochondrial DNA (mtDNA). Researcher G. Barbaro and colleagues correlated the ultrastructural findings of liver biopsy specimens with the lipoperoxidation markers and contents of mtDNA in chronic hepatitis C (CHC) patients with a different HCV genotype (“Hepatocellular Mitochondrial Alterations in Patients with Chronic Hepatitis C:…

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