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Is it possible that differences in post-translational modifications between samples will cause differences in labelling efficiency?

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Is it possible that differences in post-translational modifications between samples will cause differences in labelling efficiency?

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If post-translational modifications affect the labelling, these will affect the labelling with each of the different CyDyeâ„¢ DIGE Fluor minimal dyes to the same degree. However, we have never seen this phenomenon before.

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