Is Maturation Required for Langerhans Cell Migration?
Gwendalyn J. Randolph Carl C. Icahn Institute for Gene Therapy and Molecular Medicine, Mount Sinai School of Medicine, New York, NY 10029 Address correspondence to Gwendalyn J. Randolph, Carl C. Icahn Institute for Gene Therapy and Molecular Medicine, 1425 Madison Ave., Box 1496, New York, NY 10028. Phone: 212-659-8262; Fax: 212-803-6740; E-mail: gwendalyn.randolph{at}mssm.edu’ + u + ‘@’ + d + ”//–> Key papers in scientific literature sometimes bring a definitive resolution to a long-awaited issue. Others may be far less decisive but importantly implore us to question the fitness of prevailing models. So it is that a paper in this issue by F. Geissmann and colleagues (1), albeit subject to some variety of interpretation, nevertheless compels us to reexamine the widely accepted idea that migration of Langerhans cells in response to inflammatory stimuli is necessarily coupled to and follows from their maturation. It is well established that in the steady-state Langerhans cells turn ove
