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Is pemetrexed likely to work where methotrexate hasn ?

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Is pemetrexed likely to work where methotrexate hasn ?

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They are related to the treatment of cancer, but their indications are different. Methotrexate is an antifolate drug, it acts by inhibiting the metabolism of folic acid. Pemetrexed is chemically similar to folic acid and is in the class of chemotherapy drugs called folate antimetabolites.

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