Is Systemic Disease in the Coelomic Epithelium Associated With BRCA1 Germline Mutations?

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Is Systemic Disease in the Coelomic Epithelium Associated With BRCA1 Germline Mutations?

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Affiliations of authors: Department of Medical Oncology (PP, SD), Department of Surgery (PM), Unit of Genetics (BBP), Department of Pathology (AS), Institut Gustave-Roussy, Villejuif Cedex, France Correspondence to: Patricia Pautier, MD, Service de GynĂ©cologie MĂ©dicale, Institut Gustave-Roussy, 39 rue Camille-Desmoulins, 94805 Villejuif Cedex, France (e-mail: pautier{at}igr.fr’ + u + ‘@’ + d + ”//–>) Although most ovarian cancers associated with germline mutations in BRCA1 have serous or endometrial histology, other types of ovarian tumors, including mucinous and transitional cell ovarian tumors, have been described (1,2). However, only two cases of malignant ovarian transitional cell tumors have been reported so far that are associated with mutations in BRCA1 (i.e., 1136insA and 5382insC mutations) (3,4). Here, we report two new cases of malignant ovarian transitional cell tumors in patients carrying germline mutations in BRCA1. Neither patient had a history of other carcinomas. How