Is the cognitive function of older patients affected by antihypertensive treatment?
Martini Prince, Anne S Bird, Robert A Blizard, Anthony H Mann Abstract Objective – To establish whether initiation of treatment with diuretic or Beta blocker is associated over 54 months with change in cognitive function. Design – A cognitive substudy, nested within a randomised, placebo controlled, single blind trial. Setting – 226 general practices from the Medical Research Council’s general practice research framework. Subjects – A subset of 2,584 subjects sequentially recruited from among the 4,396 participants aged 65-74 in the trial of treatment of hypertension in older adults. The 4,396 subjects were randomised to receive diuretic, Beta blocker, or placebo. Subjects had mean systolic pressures of 160-209 mm Hg and mean diastolic pressures under 115 mm Hg during an eight week run in. Outcome measures – The rate of change in paired associate learning test (PALT) and trail making test part A (TMT) scores (administered at entry and at 1, 9,21, and 54 months) over time. Results – The
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