Is there a need for Committee on Human Research (CHR) review of proposed research at UCSF if an investigator intends to work on Human Embryonic Stem Cells (HESC)?
Yes. The CHR is UCSF’s Institutional Review Board (IRB). California Law requires IRB approval for any research involving derivation and use of human embryonic stem cells, human embryonic germ cells, and human adult stem cells from any source, including somatic cell nuclear transplantation. CHR review is needed even for uses of human stem cells that might be exempt from IRB review under Federal law. If an investigator (at UCSF) receives human embryos or HESC from another investigator (or institution), what obligation does the receiving investigator have to ensure that the consent obtained by the sending institution is adequate? It is important to respect donors’ wishes, whether they donate embryos no longer needed for assisted reproduction or donate the oocytes or sperm that are used to create the embryos. Generally researchers are not expected to verify IRB review and adequate consent when they receive established, commercially available, de-identified cell lines. For almost all other
Related Questions
- Is there a need for Committee on Human Research (CHR) review of proposed research at UCSF if an investigator intends to work on Human Embryonic Stem Cells (HESC)?
- How can I determine whether my proposed use of human subjects or human subjects data needs review by the Committee on the Use of Human Subjects?
- HRRC (Human Research Review Committee) registration number?
