Is there an increased risk of small for gestational age (SGA) outcomes in neonates born to WWE?
Conclusion • Neonates of WWE taking AEDs probably have an increased risk of SGA of about twice the expected rate (two Class II studies). Recommendation • Pregnancy risk stratification should reflect that the offspring of WWE taking AEDs during pregnancy probably have an increased risk of SGA. Further, AED use in WWE during pregnancy should be considered in the differential diagnosis of SGA in their offspring (Level B). Is there an increased risk of perinatal death in neonates born to WWE? Conclusion • There is probably no substantially increased risk of perinatal death in neonates born to WWE (two Class II studies). Recommendation • Pregnancy risk stratification should reflect that neonates born to WWE probably do not have a substantially increased risk of perinatal death (Level B). Are Apgar scores lower in neonates born to WWE? Conclusion • Neonates of WWE taking AEDs possibly have an increased risk of 1-minute Apgar scores of <7 of about twice the expected rate (one Class II study).
