Is there any stimulus that can induce the cells to become mesenchymal cells (trans-differentiation) and can we use the trans-different cells for the therapy?
This is in research level. It was noted that paracrine factors such as TGF-beta will be useful in transforming other cells into mesenchymal stem cells (MSC). Also it is reported that MSC therapy is safe to use and the injection of MSC in the muscle will transform the stem cells into muscle cells. The safety of usage needs to be considered because if there is any non -specific transformation happens, it will be unsafe.