Is there genomic evidence to support lobular breast cancer progression?
Compelling evidence for progression has yet to be reported. Advances in the resolution of array-CGH technology allow specific identification of genomic breakpoints. As such, studies identifying identical genomic breakpoints in solitary lobular neoplastic lesions and solitary ILC would provide strong support for progression from premalignant to invasive disease. Loss at 16q and gain at 1q have been suggested to be frequent events linked to progression, but identical breakpoints within these, or novel loci, would provide direct evidence linking genomic alterations to breast cancer progression.
