Is zidovudine effective in asymptomatic Chinese HIV carriers?
Human immunodeficiency viral (HIV) infection has spread to almost every country in the world and Asia will be the most prevalent area in year 2000. Zidovudine (AZT) has been documented to be effective in the treatment of acquired immunodeficiency syndrome (AIDS) and in the prophylactic therapy of asymptomatic HIV infection in western countries. However, the effectiveness of AZT to delay the development of AIDS in Chinese HIV carriers has not been reported in. We have recruited 282 HIV infected Chinese people in Taiwan since March 1988 to September 1993. Most of these patients were male, asymptomatic, aged 25-34. AZT was given to 133 patients after written informed consent. These patients were followed up regularly every 3 months with the measurement of complete blood cell count, number of CD4 and CD8 T cell and physical examination. The number of CD4 T cell increased as early as 3 months after AZT treatment compared to that at the recruitment and lasted up to 15 months after treatment.
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