Serum Immunofixation test result – What does IgG Kappa monoclonal protein detected in serum immunofixation test mean?
Hi, The patient in question is being worked up for suspected multiple myeloma. Patients with multiple myeloma secrete abnormal levels of certain proteins called M protein. The investigation of M protein involve the following steps. First, the M protein is detected using protein electrophoresis. Second, the nature of the M protein is identified using Immunoelectrophoresis or Immunofixation. Lastly, the amount of M protein may be quantified using a test known as Single Radial Immunodiffusion or other techniques. To give a brief background, Protein Electrophoresis is used to seperate out the different protein classes present in blood serum using a small electric current. The seperated protein classes form different bands, and these are labelled as Albumin, Alpha 1, Alpha 2, Beta, and Gamma. The doctors are specifically interested in the Gamma band, and check if this Gamma band on electrophoresis is broad or narrow. Normal patients have a diffuse, broad Gamma band. In patients with multipl
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