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Should a patient who developed acute renal failure induced by high dose methotrexate and required glucarpidase rescue be re-challenged with methotrexate assuming good full renal recovery?

April 26, 2017acute dose failure high induced methotrexate patient renal

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Should a patient who developed acute renal failure induced by high dose methotrexate and required glucarpidase rescue be re-challenged with methotrexate assuming good full renal recovery?

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Patients who develop acute renal failure induced by high dose methotrexate should not be re-challenged with methotrexate unless there has been an obvious precipitating factor which could be avoided.