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The one-gene-one-enzyme hypothesis does not hold: many enzymes are the product of multiple genes and many genes encode for multiple proteins. Also, there are RNA gene products (e.g., microRNA) that never get transcribed into proteins. The central dogma, while fraught with exceptions (e.g., reverse transcriptase) may nonetheless be an important principle to introduce to our students.
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Should teachers still teach one gene-one enzyme hypothesis and the Central Dogma?
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