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sulfamethoxazole therapy in outpatients: is hyperkalemia a significant problem?

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sulfamethoxazole therapy in outpatients: is hyperkalemia a significant problem?

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Author(s): Alappan R, Buller GK, Perazella MA Affiliation(s): Staywell Health Center, Waterbury, Conn., USA. Publication date & source: 1999, Am J Nephrol., 19(3):389-94. Publication type: Clinical Trial; Randomized Controlled Trial A prospective, randomized clinical study was undertaken to determine the effect of standard-dose trimethoprim-sulfamethoxazole combination treatment on serum potassium concentrations in outpatients treated in an ambulatory clinic. Ninety-seven patients were treated with oral antibiotics for a variety of infections. Fifty-one patients treated with trimethoprim-sulfamethoxazole (trimethoprim, 320 mg/day; sulfamethoxazole, 1,600 mg/day) constituted the treatment group, while 46 patients treated with other antibiotics served as controls. Serum potassium, sodium, and chloride concentrations, serum carbon dioxide content, blood urea nitrogen level, serum creatinine level, and serum glucose concentration were measured. The baseline serum potassium concentration in

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