The question I have is about Vd, apparent volume of distribution. Can you give a more concrete explaination of how what Vd means and how Vd can be more than 42 liters?
Vd is the apparent volume of a compartment in the body into which a drug distributes. The apparent volume of this compartment is determined by: Vd = Dose of drug administered/ plasma level of free drug. If the drug is localized at sites (proteins, tissues, etc.) in the body then the volume of distribution can be very high. A good example of this is digoxin which has a volume of distribution which is 15-fold greater than total body water (see Pharmkin problem set).
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