Was the AZFc microdeletion inherited and is there a paternal age effect?
Twelve fathers of AZFc-deleted men were tested and none showed a Y-chromosomal microdeletion, adding to previous data suggesting that, for most affected men, the microdeletion is a de-novo event. WHT 2928 and WHT 3432 are fraternal twins naturally conceived from an AZFc-intact father. Therefore, this brother pair is unique when contrasted to all other AZFc-deleted brothers reported whose fathers are also AZFc-deleted (Chang et al., 1999; Saut et al., 2000). Taken together, these different scenarios suggest three possibilities for the timing of an AZFc deletion. If AZFc region homologous recombination occurs during mitosis in one of the father s spermatogonia, he may have a resultant derivative cohort of AZFc-deleted spermatogonia. The ultimate numbers present in the testis would depend upon how early in the spermatogonial lineage the event occurred (stem cell spermatogonia versus more differentiated forms such as type A and type B) and how severely the deletion restrained proliferation
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