We have a patient on EURAMOS 1 who should be having surgery this week but not sure if this is going to go ahead. Should we be giving additional methotrexate if surgery is delayed?
Patients should have no more than six courses of methotrexate (MTX) administered before surgery to be eligible for randomization. If the patient has already had 4 courses of MTX (i.e. in cycle 1 and 2) then another 2 courses of MTX could be given before surgery. If given, this additional MTX should be recorded on the Chemotherapy form for cycle 2 (questions 14-16 should be answered).
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