Were interactions sought and controlled for? Were risk estimates calibrated?
Evidence tables were constructed to summarize the best evidence about effectiveness pertaining to each question. No randomized trials and only a few quasiexperimental studies were available for questions 1 and 2. There were a large number of relevant observational studies of important relationships (for example, the relation of patient characteristics to outcome); studies that concerned individual causal links or relationships in evidence tables were not summarized. For question 3, addressing cognitive rehabilitation, 15 randomized controlled trials and comparative studies that met specified inclusion criteria were placed into evidence tables. All comparative studies located for the last two questions, which addressed supported employment and care coordination, were included in evidence tables.