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What antiarrhythmic agents are safe and effective?

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What antiarrhythmic agents are safe and effective?

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Finding safe antiarrhythmic drugs for people with heart failure is an active area of study. Currently only two medicines are clearly safe and effective for the prevention of ventricular arrhythmias in people with heart failure: • Beta-blockers • Amiodarone Beta-blockers have been proved to increase the survival of people with heart failure. It is not entirely clear how this occurs, but it is suspected that a major factor is their ability to prevent ventricular arrhythmias. Beta-blockers can be very effective at preventing single abnormal beats of the heart muscle, called premature ventricular contractions, which experts think are a common trigger of ventricular arrhythmias. These beneficial effects have been observed for essentially all beta-blockers. The ability of beta-blockers to prevent ventricular arrhythmias further emphasizes why all people with heart failure should be taking them. Of equal importance, beta-blockers do not have any proarrhythmic effects, even in people with very

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