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What are the advantages and disadvantages of transdermal administration of prohormones when compared to sublingual/nasal administration?

April 26, 2017Administration advantages disadvantages nasal prohormones sublingual transdermal

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What are the advantages and disadvantages of transdermal administration of prohormones when compared to sublingual/nasal administration?

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Sublingual (absorption in the mouth, like a lozenge) and nasal delivery is limited by the amount that can be absorbed by the mucous membranes. The maximum amount of hormone that can be delivered is around 25 mg, and blood levels are elevated for 2-3 hours, compared to ~12 for transdermal. Therefore, sublingual and nasal prohormones must be dosed at least 5 times a day to be effective. However, sublingual/nasal delivery delivers 80-90% of the actives to the bloodstream, making it a very efficient carrier. A combination of transdermal application (for steady blood levels) and sublingual/nasal application (to spike blood levels, particularly pre-workout) could be effective.