What are the clinical benefits of Sandostatin® for patients with acromegaly?
Cardiovascular disease is widely acknowledged as one of the most important complications of acromegaly, accounting for much of the mortality associated with the condition. Long-term studies with both Sandostatin® and Sandostatin® LAR® have shown that normalization of GH and IGF-1 levels is associated with improved cardiac performance in patients with acromegaly.38-40 During a 6-month investigation of Sandostatin® LAR® in acromegaly, recovery of left ventricular hypertrophy occurred in 55% of patients achieving normalized hormone levels.38 Similarly, in another study cardiac performance was normalized in 50% of patients receiving subcutaneous Sandostatin® at a 5-year follow-up.39 Treatment is also particularly effective in reducing the debilitating headaches that are characteristic of acromegaly,32 symptoms of fatigue,41 and sleep apnoea.42 Indeed, in some patients, headache has been relieved within minutes of Sandostatin® administration.43 Studies have shown that other symptoms of acro
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