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What Are the Rationales for Oral Anticoagulants in Patients with Atrial Fibrillation?

April 26, 2017anticoagulants atrial fibrillation oral Patients rationales

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What Are the Rationales for Oral Anticoagulants in Patients with Atrial Fibrillation?

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Atrial fibrillation (AF) may be paroxysmal or chronic and is found in about 0.4% of the adult population. The prevalence of AF increases with age and is detected in about 15% of normal people over 75 years. Globally, AF increases the relative risk of stroke by six times and is associated with an absolute risk of approximately 5-8% per year. The risk of stroke greatly increases with the associated cardiac disorders (previous myocardial infarction, angina, history of heart failure, left atrial dilatation, left-ventricular dysfunction, mitral calcification, and a history of previous thromboembolism).