What are the recommendations for dosage and administration of Sandostatin® in patients with acromegaly?
The recommended starting dose of Sandostatin® in acromegaly is 150 g/day, given subcutaneously in three 50 g doses (t.i.d.); however, the dose of Sandostatin® used to treat acromegaly must be individualized for each patient and titrated for optimal response.21 Indeed, a recent study found that men with acromegaly may require a higher dose of Sandostatin® than women due to gender-specific differences in GH sensitivity;22 however, no age-specific effects have been observed.23 The dose of Sandostatin® most commonly found to be effective is 100 g t.i.d. (300 g/day), but some patients may require up to 500 g t.i.d. (1500 g/day) for maximum effectiveness. In order to achieve a uniform reduction of GH and IGF-1 levels throughout the day, some investigators have reported that Sandostatin® can also be administered by continuous subcutaneous infusion. Studies have demonstrated that when Sandostatin® is administered by this method it avoids the fluctuations in hormone levels seen with intermitten
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